http://pdf.reuters.com/Regnews/regnews.asp?i=43059c3bf0e37541&u=urn:newsml:reuters.com:20090604:RnsD3345T
                                                                                                                       .
RNS Number : 3345T

Alizyme PLC

04 June 2009


  For immediate release   4 June 2009


ALIZYME PLC


  TR - 1:   NOTIFICATION OF MAJOR INTERESTS IN SHARES



  1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:ii
                                                                Alizyme plc
  2 Reason for the notification(please tick the appropriate box or boxes):
  An acquisition or disposal of voting rights

                                    No
  An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already
issued to which voting rights are attached
                                      No
  An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

                                    No
  An event changing the breakdown of voting rights

                                    No
  Other (please specify):                                                          Changes to disclosure requirements

                                    Yes
  3. Full name of person(s) subject to the notification obligation:iii
                               Gartmore Investment Limited
  4. Full name of shareholder(s)(if different from 3.):iv
                               EquitiesHSBC Global Custody Nominee UK Ltd8,726,452 shares (3.947%)Nortrust Nominees
Limited8,150,388 shares (3.686%)Gartmore Growth

                               Opportunities2,349,203 shares (1.063%)BNY GIL CLT Account Nominees Ltd7,897,268 shares
(3.572%)Contract for DifferenceVidacos Nominees

                               Ltd A/C 230322,049,534 shares (9.973%)
  5. Date of the transaction and date on which the threshold is crossed or reached:v
                               1 June 2009
  6. Date on which issuer notified:
                               3 June 2009
  7. Threshold(s) that is/are crossed or reached:vi, vii
                               22%
  8. Notified details:
  A: Voting rights attached to sharesviii, ix
  Class/type of sharesif possible using the ISIN CODE   Situation previous to the triggering transaction
           Resulting situation after the triggering transaction
                                                        Number of Shares                              Number of Voting
Rights       Number of shares                          Number of voting rights
           % of voting rights x

           Direct                                    Directxi                                     Indirectxii
         Direct                     Indirect
  Ordinary SharesGBP 0.02GB0000374289                   26,724,669                                    26,724,669
           27,123,311                                                                             27,123,311
                                    12.268%

  B: Qualifying Financial Instruments
  Resulting situation after the triggering transaction
  Type of financial instrument                                                               Expiration datexiii
 Exercise/ Conversion Periodxiv                                                  Number of voting rights that may be
acquired if the instrument  % of voting rights

                                                                                 is exercised/ converted.


  C: Financial Instruments with similar economic effect to Qualifying Financial Instrumentsxv, xvi
  Resulting situation after the triggering transaction
  Type of financial instrument                                           Exercise price
Expiration datexvii          Exercise/ Conversion periodxviii            Number of voting rights instrument refers to
   % of voting rightsxix, xx
  CFD
                                                                22,049,534
Nominal                                   Delta


9.973%

  Total (A+B+C)
  Number of voting rights
                                          Percentage of voting rights
  49,172,845
                                          22.240%



  9. Chain of controlled undertakings through which the voting rights and/or the
  financial instruments are effectively held, if applicable:xxi


  Proxy Voting:
  10. Name of the proxy holder:
  11. Number of voting rights proxy holder will cease to hold:
  12. Date on which proxy holder will cease to hold voting
  rights:

  13. Additional information:
  14. Contact name:               Nick Blech, Company Secretary
  15. Contact telephone number:   +44 (0) 1223 896000



This information is provided by RNS

The company news service from the London Stock Exchange

  END

HOLVXLFBKQBXBBX